Prof. Manuela Aragno

Professore/Professoressa associato/a



Curriculum vitae

Pubblicazioni selezionate

Nigro, Debora, Menotti, Francesca, Cento, Alessia S, Serpe, Loredana, Chiazza, Fausto, Dal Bello, Federica, Romaniello, Francesco, Medana, Claudio, Collino, Massimo, Aragno, Manuela, Mastrocola, Raffaella (2017)
Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver.

Mastrocola, Raffaella, Aragno, Manuela, Alloatti, Giuseppe, Collino, Massimo, Penna, Claudia, Pagliaro, Pasquale (2017)
Metaflammation: tissue-specific alterations of the NLRP3 inflammasome platform.

Aragno, Manuela, Mastrocola, Raffaella (2017)
Dietary sugars and endogenous formation of advanced glycation endproducts: Emerging mechanisms of disease.

Sansoè, G, Aragno, M, Mastrocola, R, Parola, M2 (2016)
Dose-dependecy of clonidine's effects in ascitic cirrhotic rats: Comparison with ?1-adrenergic agonist midodrine.

Mastrocola, R, Nigro, D, Chiazza, F, Medana, C, Dal Bello, F, Boccuzzi, G, Collino, M, Aragno, M (2016)
Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice.

Sansoè, Giovanni, Aragno, Manuela, Mastrocola, Raffaella, Mengozzi, Giulio, Parola, Maurizio (2016)
Alpha-2A Adrenoceptor Agonist Guanfacine Restores Diuretic Efficiency in Experimental Cirrhotic Ascites: Comparison with Clonidine.

Mastrocola, Raffaella, Nigro, Debora, Cento, Alessia S, Chiazza, Fausto, Collino, Massimo, Aragno, Manuela (2016)
High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons.

Sansoè, Giovanni, Aragno, Manuela, Mastrocola, Raffaella, Mengozzi, Giulio, Novo, Erica, Parola, Maurizio (2016)
Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data.

Mastrocola, Raffaella, Penna, Claudia, Tullio, Francesca, Femminò, Saveria, Nigro, Debora, Chiazza, Fausto, Serpe, Loredana, Collotta, Debora, Alloatti, Giuseppe, Cocco, Mattia, Bertinaria, Massimo, Pagliaro, Pasquale, Aragno, Manuela, Collino, Massimo (2016)
Pharmacological inhibition of NLRP3 inflammasome attenuates myocardial ischemia/reperfusion injury by activation of RISK and mitochondrial pathways.

Mastrocola, Raffaella, Collino, Massimo, Penna, Claudia, Nigro, Debora, Chiazza, Fausto, Fracasso, Veronica, Tullio, Francesca, Alloatti, Giuseppe, Pagliaro, Pasquale, Aragno, Manuela (2016)
Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice.

Sansoe', , Giovanni, Aragno, Manuela, Mastrocola, Raffaella, Parola, Maurizio (2016)
Pathogenesis of Solute-Free Water Retention in Experimental Ascitic Cirrhosis: Is Vasopressin the Only Culprit?

Mastrocola, R, Nigro, D, Cento, As, Schiano, G, Chiazza, F, Dal Bello, F, Romaniello, F, Collino, M, Medana, C, Aragno, M (2016)
Pyridoxamine prevents diet-induced insulin resistance through the regulation of ceramide/sphingosine/sphingosine-1-phosphate equilibrium in mice liver.

Cento, Alessia Sofia, Nigro, Debora, Chiazza, Fausto, Dal Bello, Federica, Romaniello, Francesco, Collino, Massimo, Medana, Claudio, Aragno, Manuela, Mastrocola, Raffaella (2016)
Advanced Glycation End Products Inhibition Restores Sphingolipid Rheostat in Mice Liver and Prevents Diet-Induced Insulin Resistance.

Chiazza, Fausto, Couturier-Maillard, Aurélie, Benetti, Elisa, Mastrocola, Raffaella, Nigro, Debora, Cutrin, Juan C, Serpe, Loredana, Aragno, Manuela, Fantozzi, Roberto, Ryffel, Bernard, Thiemermann, Christoph, Collino, Massimo (2015)
Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice.

de Stefanis, Daniela, Mastrocola, Raffaella, Nigro, Debora, Costelli, Paola, Aragno, Manuela (2015)
Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle.

Mastrocola R, Collino M, Nigro D, Medana C, Dal Bello F, Chiazza F, Boccuzzi G, Aragno M (2015)
Fructose-derived advanced glycation end-products induce a negative crosstalk between lipogenesis and muscle reprogramming in mice through SREBP-1c.

Femminò, S, Chiazza, F, Mastrocola, R, Tullio, F, Penna, C, Nigro, D, Alloatti, G, Cocco, M, Garella, D, Bertinaria, M, Fantozzi, R, Aragno, M, Collino, M, Pagliaro, P (2015)
Is NLRP3 inflammasome a new pharmacological target in myocardial ischemia/reperfusion injury?

Tullio, F , Chiazza, F , Mastrocola, R , Penna, C , Nigro, D , Fracasso, V , Alloatti, G , Fantozzi, R , Aragno, M , Collino, M , Pagliaro, P (2015)
Exacerbation of myocardial ischemia/reperfusion injury induced by high-fat-high-fructose (HFHF) diet: Role of NLRP3 inflammasome.

Mastrocola R, Collino M, Nigro D, Chiazza F, D', Antona G, Aragno M, Minetto MA (2015)
Accumulation of Advanced Glycation End-Products and Activation of the SCAP/SREBP Lipogenetic Pathway Occur in Diet-Induced Obese Mouse Skeletal Muscle.

Federica Dal Bello, Valentina Santoro, Manuela Aragno, Raffaella Mastrocola, Claudio Medana, Claudio Baiocchi (2014)

Sansoe G, Mastrocola R, Aragno M, Parola M (2014)
Dynamics of sodium retention in preascitic cirrhotic rats assessed through parathyroid hormone injection.

Raffaella Mastrocola, Debora Nigro, Fausto Chiazza, Massimo Collino, Manuela Aragno (2014)
Fructose-Derived Advanced Glycation End-Products Evoke Skeletal Muscle Damage in Mice by Multiple Interference with SCAP-SREBP Pathway.

M Collino, E Benetti, M Rogazzo, F Chiazza, R Mastrocola, D Nigro, J C Cutrin, M Aragno, R Fantozzi, M A Minetto, C Thiemermann (2014)
A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice.

Collino M, Mastrocola R, Nigro D, Chiazza F, Aragno M, D', Antona G, Minetto MA (2014)
Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles.

Massimo Collino, Elisa Benetti, Mara Rogazzo, Raffaella Mastrocola, Muhammed M Yaqoob, Manuela Aragno, Christoph Thiemermann, Roberto Fantozzi (2013)
Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR- agonism correlates with impaired NLRP3 inflammasome activation.

M Rogazzo, M Collino, E Benetti, F Chiazza, R Mastrocola, M Minetto, M Aragno, C Thiemermann, R Fantozzi (2013)
Inflammatory signaling and insulin resistance caused by sugar intake: modulation by PPAR-? agonism.

E Benetti, M Collino, M Rogazzo, F Chiazza, R Mastrocola, M Aragno, M Minetto, C Thiemermann, R Fantozzi (2013)
A nonerythropoietic peptide analog of erythropoietin decreases susceptibility to diet-induced insulin resistance.

Benetti E, Mastrocola R, Rogazzo M, Chiazza F, Aragno M, Fantozzi R, Collino M, Minetto MA (2013)
High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR- ? Agonism.

Mastrocola R, Collino M, Rogazzo M, Medana C, Nigro D, Boccuzzi G, Aragno M (2013)
Advanced glycation end-products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose drinking mice.

Gaia S, Olivero A, Smedile A, Ruella M, Abate ML, Fadda M, Rolle E, Omdé P, Bondesan P, Passera r, Risso A, Aragno M, Marzano A, Ciancio A, Rizzetto M, Tarella C (2013)
Multiple courses of G-CSF in patients with decompensated cirrosi: consistent mobilization of immature cells ex pressing hepatocyte markers and exploratory clinical evaluation.

Giovanni Sansoè, Manuela Aragno, Raffaella Mastrocola, Claudia Paternostro, Maurizio Parola (2013)
Calcium receptors located in fibrotic septa: a new target to reduce portal pressure in liver cirrhosis.

C Medana, P Calza, V Giancotti, F Dal Bello, M Aragno, C Baiocchi (2013)
Study of the photocatalytic transformation of synephrine: a biogenic amine relevant in anti-doping analysis.

Guglielmotto M, Aragno M, Tamagno E, Vercellinatto I, Visentin S, Medana C, Catalano MG, Smith MA, Perry G, Danni O, Boccuzzi G, Tabaton M (2012)
AGEs/RAGE complex upregulates BACE1 via NF-kappaB pathway activation.

Sansoè G, Aragno M, Mastrocola R, Mengozzi G, Novo E, Smedile A, Parola M, Rizzetto M (2012)
Inhibition of chymase-dependent production of kidney angiotensin II improves renal sodium handling and prevents ascites in experimental liver cirrhosis.

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